New secondary metabolites from the soil-derived Aspergillus versicolor QC812

A new 18,22-cyclosterol, aspersteroline A (1), and a new DMOA-derived meroterpenoid, asperterpene O (2), along with three known compounds (3 - 5), namely mer-NF8054X (3), terretonin D (4), and asperterpene J (5), were isolated from the soil-derived Aspergillus versicolor QC812. The structures of new compounds were established based on widespread spectrographic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configurations were further confirmed by comparison of calculated and experimental electronic circular dichroism (ECD) curves. The cytotoxicity of isolates was evaluated on five human tumor cell lines, 1 and 3 showed moderate cytotoxic activities against HL-60.