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Updated: May 23, 2025
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Physical activity, weekend catch-up sleep, and depressive symptoms: mediating effects of high-sensitivity C-reactive
Sun-Young Kim1, Soo In Kim2, Weon-Jeong Lim1
1Department of Psychiatry, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, 260, Gonghang-daero, Gangseo-gu, Seoul 07804, Republic of Korea.
Background:
We aimed to examine the effect of physical activity (PA) and weekend catch-up sleep (WCS) on depressive symptoms by evaluating their effects on high-sensitivity C-reactive protein (hsCRP) levels.
Methods:
Data were collected from 10,715 adults aged ≥19 years. PA and depressive symptoms were assessed using self-report scales. The WCS was calculated by subtracting self-reported average weekday sleep hours from weekend sleep hours, and serum hsCRP levels were measured using immunoturbidimetric methods. Given that depressive symptoms are characterized by their multifaceted nature, we identified specific symptoms associated with hsCRP levels. Path analysis was used to investigate the association between PA, WCS, hsCRP, and depressive symptoms, and that between PA, WCS, hsCRP, and specific symptoms related to hsCRP.
Results:
Higher levels of PA and WCS were associated with a decreased risk of depressive symptoms through lowering hsCRP levels. Among various depressive symptoms, sleep problems and appetite changes were associated with hsCRP. In pathway analyses using them as dependent variables, higher levels of PA and WCS were also associated with a decreased risk of sleep problems and appetite changes through lowering hsCRP levels.
Limitations:
The current study employed a cross-sectional design, and WCS and PA were based on participants' self-reports rather than objective measurements.
Conclusions:
Increased levels of PA and WCS may help alleviate depressive symptoms, particularly sleep problems and appetite changes, by mitigating chronic inflammation. Therefore, ensuring adequate exercise time and compensating for inadequate weekday sleep during weekends are crucial for maintaining mental well-being.
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