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Updated: May 23, 2025
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Genome-based analysis for the identification of candidate genes associated with skin-photosensitization tolerance in
Slim Ben Jemaa1, Alberto Cesarani2, Elena Ciani3
1Laboratoire des Productions Animales et Fourragères, Institut National de la Recherche Agronomique de Tunisie, Université de Carthage, Ariana 2049, Tunisia; Dipartimento Scienze Agrarie, Alimentari e Forestali, University of Palermo, Palermo 90128, Italy.
Abstract:
In ruminant livestock, skin photosensitization, caused by the ingestion of toxic plants, is relatively common and affects animal production. In this study, genotyping data from the Illumina OvineSNP50 BeadChip from two Italian local sheep breeds (Leccese and Altamurana) were used to identify putative genomic regions associated with response to skin photosensitization. We identified four genomic regions harbouring several candidate genes related to dermatitis, immune response, and coat color, that could be potentially involved in modulating photosensitization in sheep. These findings enhance our understanding of the genetic mechanisms underlying skin photosensitization in sheep and provide valuable insights into livestock adaptation to local environmental pressure.
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