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Updated: Jul 29, 2026
Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
Natural deep eutectic solvents-platostoma palustre polysaccharides/ polyvinyl alcohol nano-electrospun membranes:
Wenfeng Li1, Bingjinfeng Zhan1, Zijing Peng1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, Guangdong, China.
Abstract:
Conventional wet facial masks face critical environmental and functional limitations, including reliance on non-biodegradable polymers, preservative-dependent formulations, and inefficient transdermal delivery of bioactive macromolecules. This study developed eco-friendly nanofibrous facial membranes by integrating natural deep eutectic solvents (NADES) with electrospinning to enhance Platostoma palustre polysaccharide (PPP) delivery. The L-proline/lactic acid NADES (L-proLA) increased PPP solubility 51.63-fold through hydrogen-bond disruption, confirmed by FT-IR analysis and Kamlet-Taft parameters (α = 2.904). Electrospinning with polyvinyl alcohol (PVA) created 40-150 nm diameter nanofibers (DPNMs) enabling dual transdermal mechanisms: lactic acid's stratum corneum disruption and sustained nanofiber release. DPNM-12 achieved 10.11 ± 0.13 mg/cm2 cumulative skin permeation in 24 h. The membranes demonstrated 95.36 ± 0.17 % Staphylococcus aureus and 93.59 ± 0.15 % Escherichia coli inhibition, suppressed macrophage nitric oxide by 75.8 %, and maintained >90 % fibroblast viability. Utilizing food-grade biodegradable components (PVA, NADES) eliminated organic solvents, establishing a green platform for polysaccharide-based skincare. This technology addresses conventional masks limitations by combining antimicrobial/anti-inflammatory functions with scalable eco-friendly production.
