Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

53
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
53
Humoral Immune Responses01:36

Humoral Immune Responses

71.1K
Overview
71.1K
Complementation Tests00:49

Complementation Tests

4.8K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.8K
Language and Cognition01:27

Language and Cognition

303
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
303

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Steroid profiling in congenital adrenal hyperplasia: comparing immunoassays and LC-MS/MS accuracy.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same author

Does broad autism phenotype traits affect mother-child interaction?: a cross-sectional study from Turkey.

International journal of developmental disabilities·2026
Same author

The discriminative role of angiopoietin-like protein-3 for metabolic syndrome in polycystic ovary syndrome.

Revista da Associacao Medica Brasileira (1992)·2026
Same author

Amino acids: Missing link in preeclampsia pathogenesis?

European journal of nutrition·2026
Same author

Unveiling Hidden Trauma: Age-Specific Acute Stress Responses in Children and Adolescents after the 2023 Turkey Earthquakes.

Journal of child & adolescent trauma·2026
Same author

Assessing the performance of EWMA and CUSUM algorithms in patient-based real-time quality control of electrolytes.

Clinical chemistry and laboratory medicine·2026

Related Experiment Video

Updated: May 23, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.7K

Complement system dysfunction in autism spectrum disorder: evidence for altered C1q and C3 levels (complement system

Meltem Günaydın1, Özlem Doğan2, Fatih Günay3

  • 1Department of Child and Adolescent Psychiatry, Sanliurfa City Hospital, Sanliurfa, Turkey.

Acta Neuropsychiatrica
|May 21, 2025
PubMed
Summary

This study found lower serum C1q levels in children with autism spectrum disorder (ASD), suggesting complement system alterations may contribute to ASD pathophysiology. Reduced C1q is a significant predictor of ASD.

Keywords:
Autism spectrum disorderC1qC2C3complement systemneuroimmune dysregulation

More Related Videos

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.1K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K

Related Experiment Videos

Last Updated: May 23, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.7K
Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.1K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K

Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience

Background:

  • Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex etiology.
  • Emerging research indicates immune system dysregulation, particularly the complement system, may play a role in ASD.
  • Specific complement proteins' involvement in ASD pathophysiology requires further investigation.

Purpose of the Study:

  • To compare serum levels of key complement proteins (C1q, C2, C3, C4, MBL, L-ficolin, hsCRP) in children with ASD versus healthy controls.
  • To determine if complement protein levels correlate with ASD symptom severity.
  • To identify potential complement-based biomarkers for ASD.

Main Methods:

  • Serum samples from 44 children with ASD and 44 age/sex-matched controls were analyzed.
  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify complement protein concentrations.
  • Standardized tools (CARS, ABC, RBSC-R) assessed ASD symptom severity.

Main Results:

  • Children with ASD exhibited significantly lower serum C1q levels (p < 0.001) and lower C3 levels (p = 0.033).
  • Slightly elevated C2 levels were observed in the ASD group (p = 0.015).
  • Reduced C1q levels were identified as a significant predictor of ASD (p = 0.001), but no correlation was found with symptom severity.

Conclusions:

  • Alterations in complement system proteins, notably decreased serum C1q, are associated with ASD.
  • These findings support the hypothesis that complement system dysfunction contributes to ASD pathophysiology.
  • C1q's role in synaptic pruning and neuroimmune regulation highlights its potential significance in ASD.