Innovation through instability? Genome (dis)organisation in Trypanosoma cruzi

Chagas disease affects millions globally and is caused by Trypanosoma cruzi, a parasite with a remarkable ability to adapt and persist in complex environments. Emerging evidence suggests that this adaptability may be driven by its extensive genome instability yet the underlying mechanisms remain poorly understood. Drawing insights from related trypanosomatids, we explore how processes such as aneuploidy, copy number variations and genetic rearrangements can be strategically exploited for immune evasion, host adaptation and drug resistance, and consider whether similar processes shape the adaptive potential of T. cruzi. Unravelling the fundamental biology governing genome instability in this parasite will undoubtedly advance our understanding of its evolution, pathogenesis and resilience - crucial steps towards reducing the burden of Chagas disease.