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Published on: September 29, 2023
Recent Advances in the Photochemical Biology of Serotonin
C E Nieder1, Michael A Kienzler1
1University of Connecticut, Department of Chemistry, 55 North Eagleville Rd Unit 3060, Storrs, CT 06269-3060.
Abstract:
Serotonin (5-HT) is an endogenous neurotransmitter that plays a key role in cellular signaling. Its interactions with serotonin receptors (5-HTRs) and the serotonin transporter (SERT) influence processes as disparate as hunger, happiness, healing, and headaches. Over the last several decades, photochemical tools have been developed to observe, track, and modulate these serotonin-protein interactions. The tools tend to fit into one of four categories: photoswitches, photocages, photobiosensors, or photocross-linkers. This review examines the development and application of these photochemical tools for 5-HT, 5-HTRs, and SERT over the last ≈10 years, with an emphasis on the chemistry involved.
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