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Updated: May 23, 2025

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
Published on: June 2, 2014
EBNA1
1Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. lori.frappier@utoronto.ca.
Abstract:
EBNA1 plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with specific DNA sequences in the viral episomes. EBNA1 also interacts with several cellular proteins and cellular DNA sites to modulate multiple cellular pathways important for viral persistence and cell survival. These cellular effects are also implicated in oncogenesis, suggesting a direct role of EBNA1 in the development of EBV-associated tumours.
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