Related Experiment Video
Updated: Apr 13, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.5K
Exploring the link between periodontal disease and sperm quality: a comprehensive systematic review study
Viana Mortazavi1, Nasibeh Roozbeh2, Mojdeh Banaei2
1Gulf Medical University, Ajman, UAE.
BMC Oral Health
|May 21, 2025
Summary
Periodontal disease is linked to reduced sperm motility, abnormal morphology, and increased DNA damage in men. Maintaining oral health may support male fertility management, but more research is needed.
Area of Science:
- Reproductive Medicine
- Oral Health
- Systemic Inflammation
Background:
- Periodontal diseases are common globally and linked to systemic health issues.
- Inflammation from periodontitis may negatively affect sperm production and quality.
- This review assesses the impact of periodontal disease on male reproductive health.
Purpose of the Study:
- To systematically review and critically evaluate studies on the relationship between periodontal disease and sperm quality.
- To understand the clinical implications for male infertility.
Main Methods:
- Systematic literature search across multiple databases (PubMed, EMBASE, etc.) up to September 2024.
- Included human studies reporting on periodontal health and sperm quality parameters.
- Assessed study quality using the Newcastle-Ottawa Scale (NOS); synthesized data qualitatively.
Main Results:
- Nine studies (1,386 participants) showed periodontitis is associated with decreased sperm motility, abnormal morphology, and increased DNA fragmentation.
- Findings on sperm count and concentration were inconsistent across studies.
- Inflammatory cytokines and oxidative stress are proposed mechanisms.
Conclusions:
- Periodontal disease has systemic effects on male reproductive health.
- Oral health maintenance could be an adjunct strategy for managing male infertility.
- Further large-scale, longitudinal studies are recommended to establish causality and explore interventions.
Related Concept Videos
01:41Spermatogenesis
102.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.0K
02:07Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
01:15Sperm Transport
515
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
515
01:22Sperm Structure and Semen Composition
944
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
944
01:23Infertility in Males
226
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
226