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Pregnancy-Related Venous Thromboembolism Risk Perception and Prevention in Risk-Averse Times-Significant Change

Laura A Magee1, Roopen Arya2, Clare Boag3

  • 1Department of Women and Children's Health, School of Life Course & Population Sciences, King's College London, London, UK.

BJOG : an International Journal of Obstetrics and Gynaecology
|May 22, 2025
PubMed
Summary
This summary is machine-generated.

Venous thromboembolism (VTE) caused 45 UK maternal deaths between 2020-2022. Identifying and managing VTE risk effectively in pregnant women requires a new approach to minimize harm and improve outcomes.

Keywords:
haematologymaternity servicesrisk perceptionvenous thromobemolism

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Area of Science:

  • Obstetrics and Gynecology
  • Thrombosis Research
  • Public Health

Background:

  • Venous thromboembolism (VTE) remains a significant cause of maternal mortality in the UK.
  • Despite existing risk assessments and low molecular weight heparin (LMWH) prophylaxis, maternal deaths from VTE persist.
  • Clinicians may overestimate VTE risk, impacting treatment decisions.

Purpose of the Study:

  • To address the challenge of efficiently identifying and minimizing VTE risk in pregnant and postpartum women.
  • To propose a cost-effective and safe therapeutic strategy for VTE prevention in this population.
  • To improve outcomes and reduce maternal mortality associated with VTE.

Main Methods:

  • Analysis of maternal death data related to VTE in the UK (2020-2022).
  • Review of current risk assessment protocols and thromboprophylaxis practices.
  • Development of a proposed strategy for risk identification and management.

Main Results:

  • 45 maternal deaths attributed to VTE occurred between 2020 and 2022 in the UK.
  • Over 2 million maternities were recorded during the study period.
  • Existing interventions were insufficient to prevent all VTE-related maternal deaths.

Conclusions:

  • A more efficient and consistent method is needed to identify women at high risk of life-threatening thrombosis.
  • The proposed strategy aims to minimize VTE risk with acceptable, cost-effective, and safe therapies.
  • Reducing VTE-related maternal mortality requires a refined approach to risk stratification and intervention.