Biochemical and histochemical studies on alkaline phosphatase in normal and dystrophic muscle

In muscles from dystrophic mice the activity of alkaline phosphatase is 50-75% higher than in their control littermates. In the dystrophic animals all muscle fibres show strong enzyme activity. It is suggested that during dystrophy amounts of an already existing muscle alkaline phosphatase are produced rather than that a synthesis of a new isoenzyme should be initiated.