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Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
07:41

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Inflammatory signalling pathways and non-coding RNAs in myocardial infarction: insights into pathogenesis and

Sining Bi1, Lei Yu1, Yongwen Gu2

  • 1Department of Cardiology, Jinan Third People's Hospital, Jinan, China.

Folia Morphologica
|May 22, 2025
PubMed

Insights

Non-coding RNAs (ncRNAs) are crucial in regulating inflammation during acute myocardial infarction (AMI) and ischemia-reperfusion (I/R) injury. Targeting ncRNAs offers promising therapeutic strategies for advancing AMI and I/R treatment.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • RNA Biology

Background:

  • Acute myocardial infarction (AMI) and ischemia-reperfusion (I/R) injury are significant causes of morbidity and mortality.
  • Inflammation is a central pathological mechanism in AMI and I/R injury.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in regulating inflammatory processes.

Purpose of the Study:

  • To highlight the critical roles of miRNAs and competitive endogenous RNAs (ceRNAs) in myocardial infarction (MI) and I/R injury progression.
  • To explore the therapeutic potential of targeting ncRNAs in MI and I/R injury.
  • To provide an overview of current and emerging therapeutic strategies for ncRNA-based interventions.

Main Methods:

  • Literature review focusing on the role of ncRNAs in myocardial inflammation.
  • Analysis of miRNA and ceRNA involvement in the pathogenesis of MI and I/R injury.
  • Examination of therapeutic approaches targeting ncRNAs, including pharmacological, herbal, and stem cell-based methods.

Main Results:

  • Abnormal ncRNA expression exacerbates inflammatory responses in MI and I/R injury.
  • miRNAs and ceRNAs are key regulators in the progression of MI and I/R.
  • Various therapeutic strategies targeting ncRNAs show potential for alleviating inflammation and treating MI/R.

Conclusions:

  • ncRNAs, particularly miRNAs and ceRNAs, are pivotal in the inflammatory cascade of MI and I/R injury.
  • Targeting ncRNAs presents a promising avenue for novel therapeutic interventions in cardiovascular diseases.
  • Further research into ncRNA-based therapies could significantly advance the treatment of acute myocardial infarction and ischemia-reperfusion injury.
Abstract

Keywords:
inflammationmyocardial infarctionnon-coding RNAs

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