Related Experiment Video
Updated: May 23, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Iodinated contrast media (ICM) are indispensable in modern imaging, but hypersensitivity reactions (HSRs), ranging from mild urticaria to severe anaphylaxis, remain a significant and evolving clinical challenge. Although advancements in ICM formulations and HSR management, ongoing discussions and uncertainties persist, particularly regarding variable epidemiology, complex mechanisms, and debatable clinical management strategies. This review provides a comprehensive overview and insights into the epidemiology, clinical consequences, potential mechanisms, clinical management, and current controversies associated with HSRs to ICM. Ongoing research is critical, focusing on areas such as monitoring epidemiological trends, uncovering underlying mechanisms, improving risk prediction, and refining preventive, diagnostic, and therapeutic strategies. Overall, as the use of ICM continues to rise, balancing their diagnostic benefits with effective management of HSRs is essential to optimizing patient safety and clinical outcomes.
Related Concept Videos
Radiological Investigation I: X-ray and CT
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Allergic Reactions
Desensitization and Tachyphylaxis

