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Published on: May 21, 2019
Photochemical Homodimerization as a Key Step in Natural Product Synthesis
Ellie F Plachinski1, Tehshik P Yoon1
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison WI 53706 United States.
Abstract:
Photochemical dimerizations constitute a relatively simple but important class of bimolecular reactions. Nature produces several classes of dimeric natural products, some of which appear to be arise from radical or excited-state coupling reactions that could be photochemically initiated. This review focuses on natural products syntheses that exploit these photochemical dimerization reactions; selected total syntheses are discussed as examples, with particular attention given to the photochemical key step and its stereoselectivity.
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