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Systemic Lupus Erythematosus as a Risk Factor for Encapsulating Peritoneal Sclerosis: A Case Report
Aabid Mohiuddin1, Fawaz Hussain1, Leslie Lin1
1Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, USA.
Cureus
|May 22, 2025
Summary
Systemic lupus erythematosus (SLE) may increase the risk of developing encapsulating peritoneal sclerosis (EPS) in patients undergoing chronic peritoneal dialysis (PD). This case highlights the need for preventive strategies in this high-risk group.
Area of Science:
- Nephrology
- Rheumatology
- Gastroenterology
Background:
- Encapsulating peritoneal sclerosis (EPS) is a rare complication of chronic peritoneal dialysis (PD), linked to glucose degradation products and peritonitis.
- Systemic lupus erythematosus (SLE) involves immune-mediated inflammation, potentially increasing peritoneal serosa inflammation and EPS risk.
Observation:
- A young female with SLE and end-stage renal disease (ESRD) developed EPS after five years of PD.
- Her presentation was complicated by septic shock and pneumoperitoneum, necessitating exploratory laparotomy.
Findings:
- Exploratory laparotomy revealed extensive fibrous encapsulation of abdominal organs, including the liver, colon, and stomach.
- Surgical enterolysis was required to address the severe intra-abdominal fibrosis.
Implications:
- Systemic lupus erythematosus (SLE) is identified as a significant risk factor for developing EPS in PD patients.
- This case emphasizes the importance of implementing preventive measures for EPS in SLE patients undergoing long-term PD.
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