Related Experiment Video
Updated: May 23, 2025
07:50
An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
Published on: January 7, 2019
6.8K
Infective endocarditis risk scores: a narrative review
Cindy Sun-Yan Cho1, Kevin Lim1, Ivan Chi-Hin Siu1
1Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
Journal of Thoracic Disease
|May 22, 2025
Summary
Infective endocarditis risk scores lack generalizability and have unsatisfactory performance. Further research is needed for patients deemed too unstable for surgery.
Area of Science:
- Cardiology
- Infectious Diseases
- Surgical Risk Assessment
Background:
- Infective endocarditis (IE) presents significant mortality and morbidity.
- Surgical decision-making in IE is complex due to heterogeneous patients.
- Existing cardiac surgery risk models lack IE-specific factors.
Purpose of the Study:
- To review the strengths and limitations of current risk scores for infective endocarditis.
- To analyze the applicability and usefulness of IE-specific risk scores in surgical management.
- To identify patients who would benefit from interventions.
Main Methods:
- Systematic literature search in PubMed and OVID databases.
- Inclusion of articles and abstracts from inception to June 1, 2024.
- Keywords: "infective endocarditis", "risk score", "surgical futility", "operative mortality".
Main Results:
- 18 IE-specific risk scores developed since 2007.
- Scores exhibit low generalizability due to varied patient/disease factors and validation.
- Discrimination performance in validation cohorts is unsatisfactory; long-term mortality is understudied.
Conclusions:
- Risk stratification for surgically indicated but untreated IE patients is crucial.
- This specific patient population is underrepresented in current research.
- More research is needed to address the needs of these high-risk individuals.
