Related Experiment Video
Updated: May 27, 2026
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Optimizing HPV vaccine effectiveness: impact of vaccination age and dose schedule on immunogenicity and cervical
Mehran Rostami Varnousfaderani1, Zahedeh Khoshnazar1, Hamidreza Zeratie2
1Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Cervical cancer is the fourth most common cancer among women globally, claiming over 443,000 lives annually, with 98% of these deaths occurring in developing countries. Vaccination against human papillomavirus (HPV) is a preventive strategy. This review investigates the role of age at vaccination and the number of doses in determining vaccine effectiveness. Articles from 2013 to 2023 were retrieved from PubMed, Scopus, SID, and Google Scholar using keywords related to HPV, vaccine, age, and dose. The findings suggest that the highest vaccine effectiveness is observed in younger age groups (ages 9-14: 74-93%) and decreases with age. Studies indicate that while three doses provide optimal protection, a single dose may also confer significant benefits in younger populations. These findings underscore the importance of timely vaccination and adherence to dosing schedules for maximizing vaccine impact.
More Related Videos
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Related Concept Videos
01:51Vaccinations
01:27Tumor Immunotherapy
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...