Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes

The comprehensive changes and shared dysregulated signaling pathways in early stage acne remains largely unexplored. In our recently published paper entitled "Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin," we utilized single-cell RNA sequencing and spatial transcriptomics datasets from acne patients to analyze cell communication. We identified dysregulated genes linked to inflammatory responses and hyperkeratinization. This commentary discusses potential new markers across major skin cell types, including endothelial cells, fibroblasts, lymphocytes, myeloid cells, keratinocytes, and smooth muscle cells. Additionally, we discuss key dysregulated genes in acne lesions, focusing on the intricate interplay between inflammation and hyperkeratinization. Based on our findings, we explore potential FDA-approved treatments targeting two key pathways involved in acne pathogenesis. These insights provide new therapeutic targets for acne treatment.