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Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality

Martina Jolic1, Isabella Åberg1, Omar Omar2

  • 1Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 412, Gothenburg, 405 30, Sweden.

Advanced Healthcare Materials
|May 22, 2025
PubMed
Summary

Calcium pyrophosphate (Ca-PP) addition to calcium phosphate (CaP) bone graft substitutes did not impede bone formation. Ca-PP minimally affected CaP degradation, influencing bone quality and inflammatory response in sheep models.

Keywords:
calcium phosphatecalcium pyrophosphateheterotopic boneheterotopic ossificationin vivoosteoinduction

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