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Updated: May 23, 2025

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
More than seizure control: Multidimensional Outcome Reporting in Epilepsy (MORE) as a patient-centered framework
Ammar Kheder1,2
1Division of Pediatric Neurosciences, Helen DeVos Children's Hospital, Grand Rapids, Michigan, USA.
Abstract:
The Multidimensional Outcome Reporting in Epilepsy (MORE) framework addresses critical limitations in current epilepsy outcome assessment by combining seizure control, quality of life, and patients' subjective experience. Although seizure frequency is the main emphasis of traditional classifications, they overlook important aspects of patients' experience such as treatment burden, psychosocial well-being, and functional outcomes. This framework uses a 40-40-20 weighting model in three different domains and includes proven quality of life measures. Implementation issues include consideration of the subjective aspects of assessment, standardizing across settings, and integrating clinical workflow. Eleven subdomains that cover important facets of postoperative epilepsy care are included in MORE. With simple questions, these subdomains can be evaluated effectively at a standard clinic visit. The nature of the framework permits adaption to both adult and pediatric populations while upholding fundamental concepts. MORE is more in line with the principles of patient-centered care and has the potential to influence future consensus-driven outcome definitions in the field, making it an (essential consideration given the advancement of epilepsy care.
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