Research progress on regulation strategies for surface-enhanced Raman spectroscopy

As a highly sensitive analytical technology, surface enhanced Raman spectroscopy (SERS) based on localized surface plasmon resonance has been widely explored in the field of environment monitoring, food safety, material identification and biomedicine. In the field of biosensing, the design of sensing models, the regulation of enhancement factors (EFs), and the stability of detection results have always been crucial research keys. Progress in these areas has continuously expanded the application scope of SERS technology and improved the feasibility of its application. Among them, the regulation of EFs through physical enhancement and chemical enhancement is a crucial point in improving the performance of SERS. Starting from the physicochemical mechanism, this review discusses the relevant influencing parameters and then summarizes the latest regulation strategies based on the above theory, as well as special regulation methods such as E-SERS. A diverse array of regulation strategies underpinned by the SERS enhancement mechanism have been effectively harnessed to amplify the EF of the SERS system. These include a wide spectrum of metal nanostructures based on the electromagnetic mechanism (EM), as well as regulation approaches predicated on the chemical mechanism (CM), such as energy-level manipulation, defect engineering, and material coupling. In addition, it encompasses specialized regulation methods such as analyte pre-concentration. This article focuses on summarizing the principal regulation approaches that have significantly impacted SERS enhancement in recent years, complemented by specialized regulation methods, with the hope of facilitating smoother progress in future work related to SERS.