Research progress on regulation strategies for surface-enhanced Raman spectroscopy

Area of Science:

• Analytical Chemistry
• Spectroscopy
• Nanotechnology

Background:

• Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique.
• SERS utilizes localized surface plasmon resonance for signal amplification.
• Key research areas in SERS biosensing include sensing model design, enhancement factor (EF) regulation, and detection stability.

Purpose of the Study:

• To review and summarize the latest strategies for regulating SERS enhancement factors (EFs).
• To discuss the physicochemical mechanisms underlying SERS enhancement.
• To highlight specialized methods for improving SERS performance.

Main Methods:

• Discussion of physical and chemical enhancement mechanisms.
• Analysis of parameters influencing SERS enhancement.
• Summary of regulation strategies including metal nanostructures, energy-level manipulation, defect engineering, material coupling, and analyte pre-concentration.

Main Results:

• Various strategies effectively amplify SERS EFs.
• Electromagnetic (EM) and chemical (CM) mechanisms are key to enhancement.
• Specialized methods like analyte pre-concentration offer further improvements.

Conclusions:

• Effective regulation of EFs is crucial for advancing SERS technology.
• Understanding physicochemical mechanisms enables optimized SERS performance.
• Continued development of regulation strategies will expand SERS applications.