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Published on: August 30, 2012
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High-Sensitivity Blood Cell Detection via Terahertz Refractive Index Sensing in Biomedical Applications
Md Anowar Kabir1, Md Selim Hossain2, Hasan Abdullah1,3
1Department of Information and Communication Technology, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Applied Biochemistry and Biotechnology
|May 22, 2025
Summary
This study presents a novel circular photonic crystal fiber biosensor for accurate blood component detection. The innovative sensor achieves high relative sensitivity for glucose, plasma, white blood cells, and red blood cells.
Area of Science:
- Biomedical Engineering
- Optical Sensing
- Photonics
Background:
- Biosensors are crucial for analyzing biological samples.
- Accurate detection of blood components is vital for diagnostics.
Purpose of the Study:
- To introduce a novel circular photonic crystal fiber (PCF) biosensor with a hexahedron core.
- To optimize optical parameters for enhanced detection of blood components.
- To evaluate sensor performance for glucose, plasma, white blood cells (WBCs), and red blood cells (RBCs).
Main Methods:
- Simulations performed using COMSOL Multiphysics software.
- Finite Element Method (FEM) applied to solve Maxwell's equations.
- Terahertz (THz) frequency range (1.0–3.0 THz) utilized for analysis.
Main Results:
- The proposed PCF sensor demonstrates high relative sensitivity (RS) for various blood components.
- RS values achieved: ~95.02% for glucose, ~95.48% for plasma, ~96.30% for WBCs, and ~97.04% for RBCs.
- Optimal performance observed at an operational frequency of 2.20 THz.
Conclusions:
- The developed circular PCF biosensor offers reliable and accurate measurements for multiple blood components.
- The sensor shows significant potential for advanced biomedical applications.
- The design highlights the efficacy of PCF in terahertz-based biosensing.
