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Updated: May 23, 2025
Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
Janus Gold Nanodiscs with an Asymmetrically Positioned Polyaniline Nano-Urchin for Photothermal Therapy and
Eun Sook Lee1, Jinhyung Lee1, Jiwoong Kim2
1Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Republic of Korea.
Abstract:
The second near-infrared (NIR-II) window (1000-1700 nm) offers advantages in biomedical applications such as deeper tissue penetration and superior imaging contrast. Despite this potential, existing NIR-II probes are limited by biocompatibility concerns, photobleaching, and poor photostability, issues that constrain their clinical utility. This study introduces Janus-type gold nanodiscs having an asymmetrically integrated hierarchical polyaniline (PANI) structure, optimized for use as multifunctional agents for NIR-II photothermal therapy and multimodal imaging. By shifting the localized surface plasmon resonance of the gold nanodiscs─the foundation of the Janus structure─from NIR-I to NIR-II, the developed AuPANI nanodiscs achieve remarkable deep-tissue photoacoustic imaging, up to 15 mm, while also enabling highly sensitive positron emission tomography imaging through stable radiolabeling. The nanodiscs also exhibit superior photostability and notable efficacy as photoacoustic-guided photothermal therapy agents under 1064 nm irradiation. This study positions AuPANI nanodiscs as a versatile platform for NIR-II theranostics, addressing limitations of current probes and advancing their potential for precise and effective cancer treatment.
