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Related Experiment Video

Updated: May 23, 2025

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

Published on: February 14, 2019

A comprehensive antigen-antibody complex database unlocking insights into interaction interface.

Yuwei Zhou¹, Wenwen Liu¹, Ziru Huang¹

¹The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

|May 22, 2025

Summary

This summary is machine-generated.

The Antigen-Antibody Complex Database (AACDB) offers a comprehensive resource for studying antibody-antigen interactions, crucial for developing new antibody therapies. It provides accurate data and user-friendly tools for researchers.

Keywords:

antibody antigen database molecular biophysics none structural biology

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Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Area of Science:

Immunology
Biochemistry
Drug Discovery

Background:

Antibodies are vital for vertebrate immunity and have broad biomedical uses.
Understanding antibody-antigen interactions is key for drug development but faces data complexity challenges.

Purpose of the Study:

To develop a comprehensive and accurate database for antigen-antibody complexes.
To provide researchers with advanced tools for analyzing antibody-antigen interactions.

Main Methods:

Manual processing of 7498 antigen-antibody complexes.
Integration of antibody developability and antigen-drug target data.
Annotation of paratope and epitope information.

Main Results:

The Antigen-Antibody Complex Database (AACDB) is established with 7498 curated complexes.
The database corrects PDB annotation errors and includes extensive metadata.
Comprehensive paratope and epitope data are provided for immunoinformatics research.

Conclusions:

AACDB is a valuable resource for antibody therapy development, offering improved data accuracy and accessibility.
The user-friendly interface and powerful tools facilitate complex data analysis.
The database serves as a benchmark for immunoinformatics and will be regularly updated.