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Updated: Jul 15, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three new diterpenoids from the aerial parts of Callicarpa macrophylla
Liang Gou1, Rong-Shuai Li1,2, Jian-Lin Lai1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, China.
Abstract:
Three previously unreported diterpenoids, iso-gaultheric acid (1), 7α-hydroxy-karamatsuic acid (2) and iso-bodinieric acid J (3), along with seven known diterpenoids (4-10), were yielded from the 95% ethanol extract of the aerial parts of Callicarpa macrophylla Vahl. The elucidation of their structure was accomplished through integrated interpretation of physicochemical characteristics combined with multi-spectral investigations, including 1D/2D NMR, ECD and HR-ESI-MS. Anti-inflammatory activity tests were conducted on the compounds 3-9, revealing that 6 inhibited LDH release with an IC50 value of 14.79 ± 2.69 µM.
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