[⁶⁸Ga]Ga-NOTA-C-IPB-AIT: A novel radiotracer for in vivo detection of TREM-1 expression

Triggering receptor expressed on myeloid cells 1 (TREM-1) plays a critical role in the initiation and advancement of cancer. The noninvasive and rapid detection of TREM-1 expression provides a significant value for oncologic diagnosis, tumor evaluation and the guide of TREM-1-targeted therapy. In this study, we developed three peptide-based TREM-1 targeted radiotracers and evaluated their radiochemical and biological properties, in order to identify the candidate for the detection of TREM-1 expression on tumors. Among three radiotracers, [⁶⁸Ga]Ga-NOTA-C-IPB-AIT showed a high radiochemical purity (> 98 %), excellent stability and hydrophilicity, favorable binding affinity, remarkable tumor uptake, ideal tumor-to-muscle ratio, and prolonged tumor retention, indicating that it is promising for potential use in TREM-1 expression detection.