Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prevention of the stress-induced decrease in natural killer activity by using a beta-adrenergic blocker and vitamin

F Z Meerson, G T Sukhikh, K D Pletsityĭ

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Increase in the resistance of the isolated heart to heat shock while adapting to moderate physical loads].

    Biulleten' eksperimental'noi biologii i meditsiny·1995
    Same author

    [The effect of adaptation to moderate physical loads on the increase in resistance of the isolated heart to ischemia and successive reperfusion].

    Biulleten' eksperimental'noi biologii i meditsiny·1995
    Same author

    [Transport of Ca2+ by rat myocardial sarcoplasmic reticulum during suspension in an anti-orthostatic position and during the readaptation period].

    Biulleten' eksperimental'noi biologii i meditsiny·1994
    Same author

    Stress-induced arrhythmic disease of the heart--Part II.

    Clinical cardiology·1994
    Same author

    Stress-induced arrhythmic disease of the heart--Part I.

    Clinical cardiology·1994
    Same author

    [Increase in nitric oxide generation in animal tissues during adaptation to short-term stressor exposure (EPR study)].

    Biulleten' eksperimental'noi biologii i meditsiny·1994
    Same journal

    [Study of horse fatigue on change of step length].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    Same journal

    [On the peculiarities of the blood supply of the adrenals].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    Same journal

    [On the quantitative relation between concentration of penicillin and its electrokinetic effect].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    Same journal

    [The physiology and pathology of the excretory function of the small intestine; excretion of chlorine with intestinal juice].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    Same journal

    [Histophysiological peculiarities of the Sertoli stratum in the caniculi seminales].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    Same journal

    [On the mechanism of growth of secretory epithelium of the breast].

    Biulleten' eksperimental'noi biologii i meditsiny·2010
    See all related articles

    This study shows that inderal (a beta-adrenoblocker) and vitamin E can prevent stress-induced decreases in natural killer cell activity. These antioxidants combat excess catecholamines and lipid peroxidation during stress.

    Area of Science:

    • Immunology
    • Pharmacology
    • Stress Physiology

    Background:

    • Immobilization stress can suppress natural killer (NK) cell activity.
    • This suppression is linked to elevated catecholamines and lipid peroxidation.
    • Effective preventative strategies are needed to maintain immune function under stress.

    Purpose of the Study:

    • To evaluate the efficacy of inderal (beta-adrenoblocker) and vitamin E in preventing stress-induced NK cell depression.
    • To explore the roles of catecholamines and lipid peroxidation in stress-related NK cell dysfunction.

    Main Methods:

    • Animal models subjected to immobilization stress.
    • Administration of inderal and vitamin E prior to stress exposure.
    • Assessment of natural killer cell activity levels.

    Related Experiment Videos

  • Analysis of catecholamine and lipid peroxidation markers.

    • Main Results:

    • Inderal and vitamin E significantly prevented the decrease in NK cell activity caused by immobilization stress.
    • Both agents demonstrated protective effects against stressor-induced immune suppression.
    • Evidence suggests these interventions mitigate the impact of catecholamines and lipid peroxidation.

    Conclusions:

    • Inderal and vitamin E are effective in preventing immobilization stress-induced NK cell depression.
    • Targeting catecholamine action and lipid peroxidation is a viable strategy for immune protection during stress.
    • Further research can explore clinical applications of these agents for stress management.