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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Published on: January 18, 2018

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Patient reported outcomes of cerebral venous thrombosis compared to ischemic stroke

Hyunjun Ahn1, Yadi Li2, Brittany Lapin2

  • 1Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, United States.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|May 22, 2025
PubMed

Insights

Cerebral venous thrombosis (CVT) patients reported worse quality of life and pain interference compared to ischemic stroke patients, despite similar functional outcomes. This highlights the need for comprehensive care beyond traditional clinical assessments for CVT.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Patient-Reported Outcomes Research

Background:

  • Cerebral venous thrombosis (CVT) and ischemic stroke disrupt cerebrovascular flow but differ in underlying mechanisms, clinical presentation, and patient outcomes.
  • Patient-reported outcomes (PROs) are crucial for understanding the comprehensive impact of neurological conditions.

Purpose of the Study:

  • To compare patient-reported outcomes (PROs) and their longitudinal trajectories between patients with CVT and ischemic stroke.
  • To identify disparities in quality of life, pain, and mental health between these two cerebrovascular conditions.

Main Methods:

  • A retrospective cohort study matched CVT patients (1:3) with ischemic stroke patients using propensity scores.
  • PROs including PHQ-9, PROMIS Global Health, Neuro-QoL, and PROMIS scales were analyzed over time using mixed-effects models.
  • Data were collected from cerebrovascular clinics between January 2019 and April 2024.

Main Results:

  • Matched cohort included 69 CVT and 196 ischemic stroke patients (mean age 47.5 years, 62.6% female).
  • CVT patients experienced significantly worse pain interference and worsening mental health and quality of life over time compared to ischemic stroke patients.
  • Despite lower rates of brain tissue injury (30.6% in CVT), CVT patients reported comparable or worse PROs.

Conclusions:

  • CVT patients exhibit poorer patient-reported outcomes in terms of severity and temporal patterns compared to ischemic stroke patients with similar baseline characteristics.
  • Traditional clinical assessments may underestimate the full impact of CVT on patients' well-being.
  • A holistic care model is recommended for CVT, addressing a wider range of outcomes beyond vascular pathology and functional status.
Abstract

Keywords:
Cerebral venous thrombosisIschemic strokePatient health questionnairePatient reported outcomes

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