Related Experiment Video
Updated: Feb 12, 2026

Analysis and Imaging of Osteocytes
Published on: November 29, 2024
Osteocytes burn out, give bone a break
1Center for Translational Metabolism and Health, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA.
Abstract:
The pathogenic mechanisms of chronic kidney disease-induced osteoporosis are not well understood and might involve metabolic alterations and apoptosis of osteocytes. In this issue, Hsu et al. present experimental work in uremic mice and cultured mouse osteoblasts showing that impaired mitochondrial function and mitophagy in osteocytes contribute to chronic kidney disease-associated osteoporosis. They investigate new therapeutic approaches to improve mitochondrial function in the setting of increased uremic toxin levels.
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