Optimizing Image Quality in Cerebral 3D Rotational Angiography: A Study on the Impact of Voxel Size

3D rotational angiography (3DRA) is a crucial diagnostic tool for assessing neurovascular diseases. Despite its superior spatial resolution, challenges arise in visualizing minute vasculatures. This study investigates the impact of voxel size on the spatial resolution and noise of cerebral 3DRA.

3DRA data from January 2022 to May 2022 were retrospectively analyzed, including a total of 10 patients with 50 small vessels (<1.0 mm in diameter) analyzed (5 vessels per patient). Using the Artis Q biplane angiography machine, 3DRA data sets were acquired and reconstructed at various voxel sizes ranging from 0.05 mm to 0.30 mm. Quantitative assessment included measurement of vessel visibility (maximum grayscale intensity within the vessel), vessel sharpness (slope of grayscale intensity calculated between 20% and 80% of maximum intensity), and background noise (standard deviation within a nonvascular region). Qualitative assessments-sharpness, noise, and overall image quality-were evaluated by 3 neuroradiologists.

A total of 50 vessels were analyzed quantitatively. Both the maximum intensity and slope of grayscale intensity at vessel walls decreased with increasing voxel size. There was a significant 2.94% increase in vessel intensity for every 0.05 mm decrease in voxel size (P < .001). Background noise significantly decreased as the voxel size increased (P < .001). Qualitatively, as the voxel size decreased, the sharpness of the image improved, and the amount of noise decreased. The overall image quality generally improved with decreasing voxel size. A good interrater agreement was observed among the neuroradiologists (κ = 0.601).

Voxel size significantly influences 3DRA image quality. Smaller voxel sizes enhance spatial resolution and overall image clarity despite increased noise and reduced field of view. Strategic application of smaller voxel sizes is crucial for detailed vascular assessments, such as aneurysm morphology and fine vascular structures.