Related Experiment Video

Updated: Jul 31, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

15.8K

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter

Janos Groh1,2,3,4, Ruoqing Feng5,6, Xidi Yuan6,7,8

  • 1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany. janos.groh@tum.de.

Nature Neuroscience
|May 22, 2025
PubMed

Insights

Aging causes harmful microglia activation, leading to T cell accumulation and white matter degeneration. Targeting the CXCL10-CXCR3 axis may protect brain function in aging neurodegeneration.

Area of Science:

  • Neuroscience
  • Immunology
  • Aging Research

Background:

  • Aging is a primary risk factor for neurodegeneration, impacting white matter structure and function.
  • Myelin, crucial for nerve function, is vulnerable to aging, triggering microglia activation in white matter.

Purpose of the Study:

  • To investigate microglial functions in aging-related white matter changes using mouse models.
  • To understand the role of glial-immune interactions in age-related neurodegeneration.

Main Methods:

  • Pharmacological and genetic approaches in mice.
  • Single-cell and spatial transcriptomics for glial heterogeneity analysis.
  • Investigation of the CXCL10-CXCR3 signaling pathway.

Main Results:

  • Maladaptive microglia activation promotes CD8+ T cell accumulation in aged white matter.
  • This T cell infiltration leads to myelinated axon degeneration and impaired brain function.
  • The CXCL10-CXCR3 axis is identified as critical for CD8+ T cell recruitment and retention.

Conclusions:

  • Myelin-related microglia dysfunction in aging drives detrimental adaptive immune responses.
  • Targeting the CXCL10-CXCR3 axis offers a potential therapeutic strategy for age-related white matter damage and neurodegeneration.

More Related Videos

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.8K
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

31.8K

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...