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Updated: Sep 20, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

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Medium-Chain Chlorinated Paraffins Altered Neurobehavior and Induced Neuroinflammation Associated with Disordered

Luyao Zhang¹, Danyang Zhang¹, Bufan Xu¹

¹School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Journal of Agricultural and Food Chemistry

|May 23, 2025

Summary

Medium-chain chlorinated paraffins (MCCPs) exposure caused neuroinflammation and abnormal behaviors in animal models. MCCPs also disrupted gut microbiota and promoted intestinal inflammation, suggesting a link via the microbiota-gut-brain axis.

Keywords:

intestinal flora medium-chain chlorinated paraffins microbiota–gut–brain axis neuroinflammation short-chain fatty acids

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Area of Science:

Environmental toxicology
Neuroscience
Microbiology

Background:

Chlorinated paraffins (CPs) are industrial chemicals with increasing use of medium-chain chlorinated paraffins (MCCPs) following restrictions on short-chain chlorinated paraffins (SCCPs).
MCCPs have been detected in food and animal brains, raising concerns about potential health risks.
The impact of MCCPs on intestinal homeostasis and the nervous system remains largely unknown.

Purpose of the Study:

To investigate the neurobehavioral, neurological, and gastrointestinal effects of MCCP exposure.
To elucidate the role of gut microbiota and its metabolites in MCCP-induced toxicity.
To assess the potential risks of MCCPs through the microbiota-gut-brain axis.

Main Methods:

Animal models were exposed to CP-52, a prevalent MCCP.
Evaluated neurobehavioral changes, brain histopathology (gray matter thickness, astrocyte activation), and neuroinflammation markers.
Analyzed gut microbiota composition, short-chain fatty acid (SCFA) levels, and intestinal inflammation.

Main Results:

CP-52 exposure led to abnormal behaviors, reduced gray matter thickness, astrocyte activation, and neuroinflammation.
Significant alterations in gut microbiota composition were observed.
Reduced SCFA levels and increased intestinal inflammation were detected, potentially linking gut dysbiosis to neuroinflammation.

Conclusions:

MCCP exposure poses risks to both the nervous system and intestinal homeostasis.
The gut microbiota-gut-brain axis may mediate MCCP-induced neuroinflammation.
Findings highlight the need for safety assessments of MCCPs in food and environmental contexts.