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Clinical Characteristics and Impact on Prognosis of Melanoma Accompanied by Multiple Primary Malignancies: A Retrospective Analysis

  • 0Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital and Institute, Beijing, China.
Cancer Investigation +

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May 23, 2025

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May 23, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study examined melanoma patients with multiple primary tumors, finding NRAS mutations and elevated lactate dehydrogenase (LDH) linked to worse survival. Melanoma as the first primary tumor improved outcomes.

Area Of Science

  • Oncology
  • Dermatology
  • Genetics

Background

  • Melanoma (MM) patient characteristics and prognosis, particularly acral and mucosal subtypes with multiple primary tumors, require further investigation.
  • Understanding the interplay between melanoma and other malignancies is crucial for comprehensive patient care.

Purpose Of The Study

  • To explore the clinical features and prognostic factors of patients with melanoma, especially those with multiple primary tumors.
  • To identify associations between nonmelanoma malignancies, genetic mutations, and survival outcomes in melanoma patients.

Main Methods

  • Retrospective analysis of 87 melanoma patients with single primary tumors and 87 with multiple primary malignant tumors.
  • Collection of data on nonmelanoma malignancy types, genetic testing (BRAF V600, NRAS, KIT, TP53), and survival.
  • Statistical analyses included chi-square, Fisher's exact, log-rank, and Cox regression (univariate and multivariate).

Main Results

  • Digestive system cancers were the most frequent nonmelanoma malignancies; breast cancer was more common in acral melanoma.
  • BRAF V600, NRAS, KIT, and TP53 mutations were prevalent.
  • Univariate analysis identified KIT mutations and elevated lactate dehydrogenase (LDH) as influencing overall survival (OS). Multivariate analysis linked NRAS mutations and increased LDH to worse survival, while melanoma as the first primary tumor correlated with prolonged survival.

Conclusions

  • This study provides preliminary insights into the clinical characteristics and prognosis of melanoma patients with multiple primary tumors.
  • NRAS mutations and elevated LDH levels are associated with poorer survival in this cohort.
  • Larger sample sizes are needed for more definitive conclusions regarding melanoma prognosis in patients with multiple primary malignancies.

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