Intraepithelial lymphocytes in human oral diseases

Area of Science:

• Immunology
• Oral Medicine

Background:

• Intraepithelial lymphocytes (IELs) are specialized T cells integral to mucosal immunity.
• They possess diverse phenotypes, express activation markers, and exhibit plasticity, contributing to immune regulation and defense.

Purpose of the Study:

• To systematically review the literature on the involvement and mechanisms of IELs in oral diseases.
• To explore the specific roles of IELs in the pathogenesis of various oral conditions.

Main Methods:

• A systematic literature review was performed.
• PubMed/MEDLINE databases were searched for relevant studies on IELs and oral diseases.

Main Results:

• IELs play potential roles in the pathogenesis of oral lichen planus, oral cancers, periodontal diseases, graft-versus-host disease, and primary Sjogren's syndrome.
• The review identified key characteristics and functions of IELs relevant to oral health.

Conclusions:

• IELs are significant players in the development and progression of several oral diseases.
• Further research into IEL mechanisms in oral pathology is warranted.