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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Dermis
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Murine Fetal Echocardiography
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Ichthyosis Fetalis in a Lacaune Lamb.

Arman Shokri1, Afshin Raoofi1, Sara Shokrpoor2

  • 1Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Veterinary Medicine and Science
|May 23, 2025
PubMed
Summary

This study reports a case of congenital ichthyosis in a Lacaune lamb, a rare inherited skin disorder. The lamb exhibited severe hyperkeratosis and died shortly after birth, highlighting the need for further research into lamb ichthyosis classification.

Keywords:
Lacaunehyperkeratosisichthyosislamb

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Area of Science:

  • Veterinary Dermatology
  • Animal Genetics
  • Congenital Disorders

Background:

  • Ichthyosis is a group of inherited skin disorders affecting both animals and humans.
  • It is characterized by abnormal keratinization and excessive scaling of the skin.

Observation:

  • A Lacaune lamb presented with congenital ichthyosis, exhibiting inability to stand and lateral recumbency.
  • The lamb displayed widespread hyperkeratosis and cracking of the skin, particularly on the head and neck.
  • Histopathology revealed significant thickening of the stratum corneum with compact, laminated orthokeratotic hyperkeratosis.

Findings:

  • Clinical and histopathological findings confirmed a diagnosis of ichthyosis in the affected lamb.
  • The observed abnormalities were confined to the stratum corneum, with no other epidermal layers affected.

Implications:

  • This case highlights the occurrence of ichthyosis in lambs, presenting in a severe congenital form.
  • Further research is necessary for accurate classification and understanding of ichthyosis in ovine populations.
  • Understanding genetic and pathological aspects can aid in future diagnosis and management strategies.