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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

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Increased Mortality Among Lean Versus Non-Lean Adults With MASLD: A Multicenter Study.

Leith Ghani¹, Majd B Aboona¹, Claire S Faulkner²

¹Department of Internal Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona, USA.

Journal of Gastroenterology and Hepatology

|May 23, 2025

Summary

This summary is machine-generated.

Lean individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) face higher mortality and cardiovascular risks. This study highlights the urgent need for targeted interventions and further research into this often-overlooked patient group.

Keywords:

Hispanic paradox MASLD Native American lean individuals major adverse liver outcomes mortality

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Published on: September 29, 2014

Area of Science:

Hepatology
Cardiology
Public Health

Background:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern.
The Delphi Consensus statement introduced new terminology for MASLD, necessitating updated research.
Large-scale studies comparing lean and non-lean MASLD populations are scarce.

Purpose of the Study:

To assess the prevalence and incidence of outcomes in lean versus non-lean individuals with MASLD.
To analyze mortality, cirrhosis, cardiovascular disease (CVD), major adverse liver outcome (MALO), and cancer incidence.
To investigate outcomes in a diverse, multicenter patient cohort.

Main Methods:

Retrospective multicenter study design.
Inclusion of patients from Banner and University of Michigan Health systems (2012-2023).
Analysis of mortality and incidence of cirrhosis, CVD, MALO, and cancer.

Main Results:

A cohort of 75,921 patients with MASLD was analyzed, with 5% identified as lean.
Lean individuals exhibited higher adjusted mortality rates.
Lean MASLD patients demonstrated increased incidence of CVD and MALO compared to non-lean counterparts.

Conclusions:

Lean individuals with MASLD experience disproportionately higher mortality and cardiovascular burden.
There is a critical need for further research into the specific challenges faced by lean MASLD patients.
Development of targeted interventions is essential to reduce mortality in this population.