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A fluorenone-based conjugated polymer nanoparticle applied in drug delivery with real-time detection (color change)
Shouhui Huang1,2, Lili Li3, Weihao Chen2
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China. chubz@szu.edu.cn.
Abstract:
Based on the self-assembly of conjugated polymers (CPs) with paclitaxel constructed as nanoparticles (NPs) exhibiting luminescence properties through the AILE mechanism, a novel type of pH-responsive nanoparticle was developed, featuring a color change that indicated drug molecule release. The nanoparticles (NPs) characterized by their AILE luminescence were straightforward to prepare, exhibited exceptional stability, and demonstrated a high drug loading capacity and a sensitive drug release profile under acidic conditions. These NPs could release drugs within cellular lysosomes in response to acidic environments, thereby triggering apoptosis in cancer cells. Furthermore, the release of the drug can be monitored by observing changes in the fluorescence color, which serves as an indicator signal. Additionally, by investigating the molecular interactions between PFOP-NEt3(+) and paclitaxel, we have proposed a novel mechanism for the induction of AILE luminescence.
