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Updated: Aug 6, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

Structural Basis for Medium-Chain Dehydrogenase/Reductase-Catalyzed Reductive Cyclization in Polycyclic Tetramate

Xiangqian Xie1, Fan Li1, Yanxin Mu1

  • 1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, People's Republic of China.

Journal of the American Chemical Society
|May 23, 2025
PubMed
Summary

Researchers elucidated the mechanism of a novel enzyme subclass catalyzing reductive cyclizations in polycyclic tetramate macrolactam (PoTeM) biosynthesis. Structural insights reveal hydride-mediated C-C bond formation critical for natural product synthesis.

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