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Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1

Jemma A Montgomery1, P Holland Alday1,2, Ryan Choi3

  • 1Division of Infectious Diseases, Portland VA Medical Center, Portland, Oregon 97239, United States.

ACS Infectious Diseases
|May 23, 2025
PubMed
Summary

Bumped kinase inhibitors (BKIs) target calcium-dependent protein kinase 1 (TgCDPK1) and mitogen-activated protein kinase-like 1 (TgMAPKL1) in Toxoplasma gondii. Dual targeting suggests a high genetic barrier to drug resistance, aiding therapeutic development.

Keywords:
antiparasitic drugsbumped kinase inhibitordrug mechanismkinasetherapeuticstoxoplasmosis

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