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Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants
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Glial Fibrillary Acid Protein Reflects Disease Activity in Autoimmune Encephalitis

Johannes Piepgras1, Marlene L Piepgras2, Falk Steffen1

  • 1Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

European Journal of Neurology
|May 23, 2025
PubMed
Summary

The NfL/GFAP ratio in serum and CSF shows promise as a biomarker for diagnosing autoimmune encephalitis (AE) and monitoring disease activity. This ratio aids in distinguishing AE from multiple sclerosis and identifying active AE cases.

Keywords:
autoimmune encephalitisbiomarkerglial fibrillary acid proteinneurofilamentneuroinflammation

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