Influence of an inhibition of thromboxane synthetase by imidazole on kidney function in rats during postnatal...

Imidazole, an inhibitor of thromboxane synthetase, reduced the renal excretion of sodium in saline loaded rats. Urine volume was also reduced, whereas the renal excretion of potassium and osmotically active substances was less influenced following imidazole administration. There was also a distinct effect of imidazole (0.5, 5, 10 mg/100 g b.wt. i.p., respectively) on renal excretion of p-aminohippurate. These effects are demonstrable if the urine collecting period begins 10 or 60 min after imidazole administration, but not after a longer time interval (120 min). Both renal excretion of sodium and p-aminohippurate were more diminished in adult rats compared with young animals. The renal effects observed following administration of an inhibitor of thromboxane synthetase are quite similar to effects of the cyclooxygenase inhibitors indomethacin and naproxen.