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Cannabidiol as an immune modulator: A comprehensive review
Khizra Mujahid1, Muhammad Shahzaib Rasheed2,3, Azka Sabir2
1College of Pharmacy, Chonnam National University, Gwangju, South Korea.
Summary
Cannabidiol (CBD) shows significant potential in modulating immune responses and treating inflammatory conditions. Further research into its delivery and long-term effects is crucial for its therapeutic integration.
Area of Science:
- Immunology
- Pharmacology
- Nanotechnology
Background:
- Cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa, exhibits anti-inflammatory, neuroprotective, and immunomodulatory properties.
- CBD influences immune responses by regulating T cells, inducing macrophage apoptosis, and suppressing pro-inflammatory cytokines.
Purpose of the Study:
- To comprehensively review the immunomodulatory mechanisms and therapeutic potential of Cannabidiol (CBD).
- To examine CBD's efficacy in autoimmune diseases, neuropathic pain, and cancer therapy.
- To explore advancements in CBD delivery systems and identify future research directions.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science.
- Inclusion of preclinical and clinical studies investigating CBD's effects on immune responses and related conditions.
Main Results:
- Preclinical and clinical studies support CBD's efficacy in autoimmune diseases (Type 1 diabetes, multiple sclerosis, rheumatoid arthritis, IBD), neuropathic pain, and cancer.
- Nanotechnology-based delivery systems enhance CBD's solubility, bioavailability, and targeted delivery for improved therapeutic outcomes.
- CBD demonstrates potential in wound healing and inflammation management.
Conclusions:
- CBD is a promising therapeutic agent with significant immunomodulatory effects and broad clinical potential.
- Challenges include immune response variability, limited long-term safety data, and potential drug interactions.
- Advancements in delivery systems and further research are key to integrating CBD into precision medicine and immune regulation strategies.
Keywords:
Autoimmune diseasesCannabidiolImmune cellsImmune modulationPharmacodynamicsPharmacokineticsMore Related Videos
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