Lessons Learnt From Glioblastoma Surviving 20 Years Progression Free: A Case Report
1Department of Neurosurgery, HMC Hospital and Advanced Neuro Spine Institute, Ludhiana, Punjab, India.
Abstract:
Glioblastoma (GBM), the commonest primary brain tumor, mostly dies in 2-3 years, despite all the latest advances. Shorter lifespan justifying subtotal resection for functional preservation, a common, but not optimum scenario for patients. A 22-year-old man with raised intracranial pressure and focal deficits underwent Gross total removal (GTR). Following irradiation, he has survived for over 20 years since his first brain CT, and the latest MRI has no recurrence. This case provides the possibility of giving HOPE of living long to the next suspected glioblastoma during consent or counseling and a reason to achieve GTR in most cases to find some of such lucky cases. The specimen should be preserved for newer tests in the future. Building meaningful relationships with patients is needed for long follow-ups.
Insights
This case study highlights a glioblastoma patient who survived over 20 years after gross total removal and irradiation. It suggests achieving complete tumor resection may offer long-term survival for some glioblastoma patients.
Area of Science:
- Neuro-oncology
- Neurosurgery
Background:
- Glioblastoma (GBM) is an aggressive primary brain tumor with a typically poor prognosis, often leading to short survival times.
- Current treatment strategies often prioritize subtotal resection for functional preservation, which may not be optimal for patient outcomes.
Observation:
- A 22-year-old male presented with symptoms of increased intracranial pressure and focal neurological deficits.
- The patient underwent gross total removal (GTR) of the glioblastoma.
- Following GTR and adjuvant irradiation, the patient has remained recurrence-free for over 20 years.
Findings:
- This case demonstrates a rare instance of long-term survival exceeding 20 years in a glioblastoma patient.
- Achieving gross total resection, in conjunction with radiotherapy, may be associated with prolonged survival in select glioblastoma cases.
Implications:
- This case offers hope for extended survival in glioblastoma patients and supports the pursuit of GTR when feasible.
- Preserving tissue specimens for future molecular testing and fostering strong patient-physician relationships for long-term follow-up are crucial.
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