Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue
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View abstract on PubMed
Summary
This summary is machine-generated.Researchers identified a distinct mouse beige fat depot with developmental origins and features mirroring human brown fat. This discovery offers a valuable preclinical model for metabolic disorder therapies.
Area Of Science
- Metabolic disorders
- Adipose tissue biology
- Therapeutic development
Background
- Beige adipocytes enhance energy expenditure, offering therapeutic potential for metabolic disorders.
- Understanding beige fat origins is crucial for developing effective preclinical models.
- Current knowledge gaps hinder the translation of beige fat therapies.
Purpose Of The Study
- To identify and characterize a distinct mouse beige adipose tissue (ibAT) depot.
- To compare the developmental origins and characteristics of ibAT with human beige and brown adipose tissue.
- To establish a relevant preclinical model for human beige adipose tissue.
Main Methods
- Comparative lineage tracing using Prx1+ cells.
- Morphological and molecular analysis of adipose tissue depots.
- Assessment of thermogenic activity and aging capabilities.
Main Results
- A distinct ibAT depot shares developmental origins (Prx1+ cells) with inguinal white adipose tissue (iWAT).
- ibAT exhibits higher thermogenic activity and capability during aging compared to iWAT.
- ibAT displays morphological, molecular, and developmental similarities to human supraclavicular brown adipose tissue (scBAT).
Conclusions
- A novel mouse beige adipose tissue depot has been identified.
- This ibAT depot serves as a preclinical model for human beige adipose tissue.
- Findings advance understanding of beige fat development and maintenance for metabolic disease therapies.
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