Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

133
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
133
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

27
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
27
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

70
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
70
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

46
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
46
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

39
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
39

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tailoring Antiplatelet Therapy Duration After PFO Closure: Insights From the PROLONG Registry.

JACC. Advances·2026
Same author

Long-term prognostic impact of optical coherence tomography detected plaque rupture in nonculprit coronary segments.

Atherosclerosis·2026
Same author

Evaluation of genetic-molecular causes of out-of-hospital cardiac arrest - from patients to families: the GenetiCA study.

Resuscitation plus·2026
Same author

[SICOA-GISE Consensus document on carotid atherosclerotic disease: from increased intima-media thickness to stenosis. Diagnostic and therapeutic management].

Giornale italiano di cardiologia (2006)·2026
Same author

Prognostic Impact of Pacemaker Implantation in Transcatheter Aortic Valve Replacement With Self-Expanding Prosthesis.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

ESC guidelines 2025 on cardiovascular disease and pregnancy: considerations and future perspectives.

European heart journal supplements : journal of the European Society of Cardiology·2026

Related Experiment Video

Updated: Sep 20, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.1K

Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study.

Flavio Giuseppe Biccirè1, Riccardo Di Pietro2, Shengxian Tu3

  • 1Centro per la Lotta Contro L'Infarto - CLI Foundation, Rome, Italy; Cardiovascular Sciences Department, San Giovanni Addolorata Hospital, Rome, Italy; Department of General and Specialized Surgery "Paride Stefanini", Sapienza University of Rome, Rome, Italy.

International Journal of Cardiology
|May 23, 2025
PubMed
Summary

Optical flow ratio (OFR) identifies flow-limiting coronary lesions and predicts adverse events. Combining OFR with thin-cap fibroatheroma (TCFA) identifies patients at highest risk for target-vessel failure.

Keywords:
Clinical outcomesComputed fractional flow reserveFunctional assessmentOptical coherence tomographyOptical flow ratioThin-cap fibroatheroma

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

542
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.1K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

542
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.1K

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Optical flow ratio (OFR) is a novel method to compute coronary fractional flow reserve (FFR) using optical coherence tomography (OCT).
  • The prognostic significance of OFR, particularly in conjunction with plaque morphology, requires further investigation.

Purpose of the Study:

  • To evaluate the predictive value of OFR for adverse cardiovascular outcomes.
  • To assess the combined prognostic impact of OFR and OCT-derived plaque characteristics.

Main Methods:

  • The CLIMA study prospectively enrolled patients with untreated coronary lesions analyzed by OCT.
  • OFR was calculated, and lesions were assessed for morphological features like thin-cap fibroatheroma (TCFA).
  • Primary endpoint was target-vessel failure (TVF) at 1 year; secondary endpoint was cardiac death or target segment myocardial infarction.

Main Results:

  • OFR ≤0.80 identified lesions with smaller lumen areas and higher prevalence of TCFA and large lipid arcs.
  • Flow-limiting lesions (OFR ≤0.80) were associated with a significantly higher incidence of TVF (10.8% vs. 4.8%).
  • Patients with both TCFA and OFR-defined flow limitation exhibited the highest risk for both primary and secondary endpoints.

Conclusions:

  • OFR-detected flow limitation is linked to adverse plaque morphology and increased risk of adverse events.
  • The combination of TCFA and OFR-derived flow limitation identifies patients with the highest risk profile.