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Assessment of 5 miscarriages with transcervical embryoscopy
Pinar Calis1, Gurkan Bozdag2, Mehmet Erdem1
1Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
Fertility and Sterility
|May 23, 2025
Summary
Transcervical embryoscopy effectively identifies structural anomalies in early pregnancy loss cases missed by ultrasound. This minimally invasive technique also enables uncontaminated fetal tissue collection for karyotype analysis, aiding in miscarriage etiology determination.
Area of Science:
- Reproductive Medicine
- Fetal Medicine
- Gynecologic Surgery
Background:
- Early pregnancy loss is a common complication.
- Transvaginal ultrasound is standard for diagnosing pregnancy complications.
- Limitations exist in ultrasound's ability to detect subtle embryonic structural abnormalities.
Purpose of the Study:
- To evaluate the utility of transcervical embryoscopy in diagnosing morphological abnormalities in early pregnancy loss.
- To assess the feasibility of collecting uncontaminated fetal material for genetic analysis using this technique.
Main Methods:
- A video case report detailing 5 cases of missed miscarriage.
- Patients underwent transvaginal ultrasound followed by transcervical embryoscopy.
- Embryoscopic findings were documented, and fetal tissue was retrieved for karyotype analysis.
Main Results:
- Transcervical embryoscopy successfully visualized fetal morphology and identified structural anomalies not detected by ultrasound.
- Cases included Cantrell pentalogy, hydrops fetalis, neural cord defect, and trisomy 13.
- Uncontaminated fetal material was retrieved for karyotype analysis.
Conclusions:
- Transcervical embryoscopy is a valuable tool for diagnosing morphological abnormalities in embryonic demise.
- It aids in determining the etiology of missed miscarriage.
- The procedure allows for genetic analysis and requires only an office hysteroscope, though it has a learning curve.
