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Related Experiment Video

Updated: Sep 20, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Outcomes and mortality in calciphylaxis: A multicenter update.

Colleen M Glennon1, Joyce Xia2, Lindsay Strowd3

  • 1Department of Dermatology, Duke University Medical Center, Durham, North Carolina.

Journal of the American Academy of Dermatology
|May 23, 2025
PubMed
Summary
This summary is machine-generated.

Calciphylaxis mortality has decreased, with 1-year survival now at 28.88%. Risk factors for calciphylaxis mortality include penile lesions and atrial fibrillation, while distal lesions indicate better outcomes.

Keywords:
atrial fibrillationcalciphylaxislesion distributionmortalitymulticenternephrogenicnon-nephrogenicoutcomesrace

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Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Medicine

Background:

  • Calciphylaxis pathogenesis and treatment understanding has advanced.
  • Mortality rates for calciphylaxis have shown a decrease.

Purpose of the Study:

  • To report updated calciphylaxis risk factors and outcomes.
  • To analyze data from a large, diverse, multicenter American cohort.

Main Methods:

  • Retrospective observational study across 6 academic institutions.
  • Included adult patients with a clinical calciphylaxis diagnosis from 2006-2022.

Main Results:

  • 268 patients included; 84.62% were nephrogenic cases.
  • One-year disease-specific mortality was 28.88%.
  • Penile lesions, atrial fibrillation, and dialysis at diagnosis increased mortality risk; distal lesions decreased it.

Conclusions:

  • Overall 1-year mortality is lower than historic rates (28.88% vs. 45%-80%).
  • Survival differences observed between institutions.
  • Study limitations include retrospective design and limited ethnic diversity.