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The Impact of Cardio-Renal-Metabolic Profile in Dilated Cardiomyopathy

Tamim Akbari1,2, Daniel J Hammersley1,2,3, Clarice Yau-Yee May2

  • 1Royal Brompton and Harefield Hospitals, Part of Guy's and St Thomas' NHS Foundation Trust, London, UK.

Current Cardiology Reports
|May 23, 2025
PubMed

Insights

Dilated cardiomyopathy patients often have metabolic syndrome and renal disease, worsening prognosis. Optimizing cardio-renal-metabolic health is crucial for better outcomes in these complex cases.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Diseases

Background:

  • Dilated cardiomyopathy is a major cause of heart failure globally.
  • Aging populations and increasing multimorbidity exacerbate heart failure challenges.

Purpose of the Study:

  • To describe the prevalence of metabolic syndrome and renal failure in dilated cardiomyopathy patients.
  • To explore common underlying mechanisms and evaluate outcomes.
  • To highlight novel therapeutic strategies for this patient group.

Main Methods:

  • This is a review article.
  • It synthesizes current literature on dilated cardiomyopathy, metabolic syndrome, and renal disease.
  • Focuses on pathophysiological pathways and treatment strategies.

Main Results:

  • A significant number of dilated cardiomyopathy patients present with concurrent metabolic syndrome and renal disease.
  • This multimorbidity is associated with a worse prognosis and complex treatment challenges.
  • Shared pathophysiological pathways complicate management.

Conclusions:

  • Optimizing the cardio-renal-metabolic profile is essential for managing dilated cardiomyopathy.
  • New therapeutic strategies targeting shared pathways are needed to improve patient outcomes.
Abstract

Keywords:
Dilated cardiomyopathyHeart failureMetabolic syndromeMultimorbidityObesityOutcomes

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