Survival prediction in glioblastoma: 10-year follow-up from the Dutch Neurosurgery Quality Registry
- Jeroen T J M van Dijck 1,2, Hilko Ardon 3, Rutger K Balvers 4, Eelke M Bos 4, Lisette Bosscher 5, H Bart Brouwers 3, Vincent K Y Ho 6, Koos Hovinga 7, Lesley Kwee 8, Mark Ter Laan 9, Rob J A Nabuurs 1, Pierre A J T Robe 10, Sarita van Geest 11, Olivier van der Veer 12, Niels Verburg 13, Michiel Wagemakers 14, Philip C de Witt Hamer 13, Mar Rodriguez Girondo 15, Rishi D S Nandoe Tewarie 16,17,
- 1Department of Neurosurgery, Haaglanden Medical Centre, The Hague, The Netherlands.
- 2Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.
- 3Department of Neurosurgery, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
- 4Department of Neurosurgery, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, The Netherlands.
- 5Department of Neurosurgery, Isala, Zwolle, The Netherlands.
- 6Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
- 7Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
- 8Department of Neurosurgery, Northwest Clinics, Alkmaar, The Netherlands.
- 9Department of Neurosurgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
- 10Department of Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
- 11Department of Neurosurgery, Martini Hospital, Groningen, The Netherlands.
- 12Department of Neurosurgery, Medical Spectrum Twente, Enschede, The Netherlands.
- 13Department of Neurosurgery, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
- 14Department of Neurosurgery, University Medical Centre Groningen, Groningen, The Netherlands.
- 15Section of Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
- 16Department of Neurosurgery, Haaglanden Medical Centre, The Hague, The Netherlands. r.nandoe.tewarie@haaglandenmc.nl.
- 17Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands. r.nandoe.tewarie@haaglandenmc.nl.
- 0Department of Neurosurgery, Haaglanden Medical Centre, The Hague, The Netherlands.
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View abstract on PubMed
Summary
This summary is machine-generated.Glioblastoma survival remains poor despite advances. Surgical resection and adjuvant therapy improve outcomes, but age and molecular markers significantly influence prognosis. New models aid patient-centered care.
Area Of Science
- Neuro-oncology
- Clinical Epidemiology
- Surgical Oncology
Background
- Glioblastoma is a highly aggressive primary brain tumor with poor outcomes.
- Standard treatments offer limited efficacy, necessitating improved prognostic tools.
Purpose Of The Study
- To evaluate survival and prognostic factors in glioblastoma patients.
- To develop pragmatic prognostic models for individualized patient care.
- To analyze treatment variations and outcomes in a large Dutch cohort.
Main Methods
- Prospective cohort analysis of 7621 glioblastoma patients (2012-2022).
- Univariate analysis, Kaplan-Meier curves, and Cox regression for prognostic modeling.
- Funnel plots assessed center performance and surgical volume impact.
Main Results
- Median survival was 10.4 months; 2-year survival was 17.8%.
- Factors influencing survival included age, ASA classification, Karnofsky Performance Status, extent of resection, complications, MGMT methylation, and adjuvant therapy.
- Prognostic models achieved C-indices of 0.704 (6-month) and 0.721 (2-year).
Conclusions
- Surgical resection and adjuvant therapy improve glioblastoma survival but prognosis remains poor.
- Age, premorbid condition, treatment, and molecular markers are key survival determinants.
- Developed prognostic models show potential for clinical decision-making after validation.
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